Publications from the Kavran Lab

Weingartner KA, Tran T, Tripp KW, Kavran JM. Dimerization and autophosphorylation of the MST family of kinases are controlled by the same set of residues. (2023) Biochem. J. 480(15):1165-1182.

Chang TH, Hsieh FL, Gu X, Smallwood P, Kavran JM, Gabelli SB, Nathans J. Structural insights into plasmalemma vesicle-associated protein (PLVAP): Implications for vascular endothelial diaphragms and fenestrae (2023) Proc. Natl. Acad. Sci. 120(14) e2221103120.

Bonello TT, Cai D, Fletcher GC, Weingartner KA, Pengilly V, Lange K, Liu Z, Lippincott-Schwartz J, Kavran JM, Thompson BJ. Phase separation of Hippo signalling complexes (2023) EMBO J. 42:e112863.

Koehler TJ, Tran T, Weingartner KA, Kavran JM. Kinetic Regulation of the Mammalian Sterile 20-like Kinase 2 (MST2) (2022) Biochemistry 61(16):1683-1695.

Sun Z, Xu B, Spisak S, Kavran JM, Rokita SE. The minimal structure for iodotyrosine deiodinase function is defined by an outlier protein from the thermophilic bacterium Thermotoga neapolitana (2021) J. Biol. Chem. 297(6):101385.

Tran T, Mitra J, Ha T, Kavran JM. Increasing kinase domain proximity promotes MST2 autophosphorylation during Hippo signaling (2020) J. Biol. Chem. 295(47):16166-16179.

Cairns L, Patterson A, Weingartner KA, Koehler TJ, DeAngelis DR, Tripp KW, Bothner B, Kavran JM. Biophysical characterization of SARAH domain-mediated multimerization of Hippo pathway complexes in Drosophila. (2020) J Biol Chem. 295(18):6202-6213.

Cairns L, Tran T, Fowl BH, Patterson A, Kim YJ, Bothner B, Kavran JM. Salvador has an extended SARAH domain that mediates binding to Hippo kinase. (2018) J Biol Chem. 293(15):5532-5543.

Ingavat N, Kavran JM, Sun Z, Rokita SE. Active Site Binding Is Not Sufficient for Reductive Deiodination by Iodotyrosine Deiodinase. (2017) Biochemistry. 56(8):1130-1139.

Cairns L, Tran T, Kavran JM.  Structural insights into the regulation of Hippo signaling.  (2017) ACS Chem. Biol. 12:601-610.